Mefenamic Acid: Uses, Side Effects, and How It Compares to Other Pain Relievers

When you need fast relief from pain and inflammation, mefenamic acid, a nonsteroidal anti-inflammatory drug (NSAID) used mainly for menstrual cramps and mild to moderate pain. Also known as Ponstel, it works by blocking the body’s pain signals at the source, not just masking them. Unlike acetaminophen, which only reduces fever and pain, mefenamic acid actually cuts down swelling—making it a go-to for conditions like arthritis, muscle strains, and especially heavy, painful periods.

It’s not just about taking a pill. NSAIDs, a class of drugs that includes ibuprofen, naproxen, and aspirin all work similarly, but each has its own profile. Mefenamic acid is often chosen for menstrual pain because it targets prostaglandins—hormone-like chemicals that spike during menstruation and cause cramping. Studies show it can reduce period pain better than placebo, and in some cases, as well as ibuprofen. But it’s not for everyone. People with stomach ulcers, kidney issues, or heart conditions need to be careful. Unlike topical pain creams, mefenamic acid is taken orally, so it affects your whole system, not just one area.

Many users report quick results—often within an hour—but side effects like nausea, dizziness, and stomach upset are common. That’s why some switch to alternatives like ibuprofen, a widely used NSAID with similar pain-relieving effects but often better tolerated or even acetaminophen for milder cases. It’s also worth noting that mefenamic acid isn’t typically used long-term. Most prescriptions are for short bursts, like 2–3 days during a period, to avoid complications. If you’ve tried other pain relievers and they didn’t cut it, mefenamic acid might be the missing piece—but only if your doctor says it’s safe for you.

What you’ll find below is a collection of real, detailed guides that dig into how this drug fits into the bigger picture of pain management. You’ll see how it compares to other NSAIDs, what side effects to watch for, and how route of administration (like oral vs. topical) changes outcomes. There are also posts on similar drugs like febuxostat and allopurinol that help you understand how different medications behave in the body. Whether you’re managing chronic pain, menstrual discomfort, or just trying to make sense of your prescription, these articles give you the facts—not the fluff.